Publications

2017

Whitney JC, Peterson SB, Kim J, Pazos M, Verster AJ, Radey MC, Kulasekara HD, Ching MQ, Bullen NP, Bryant D, Goo YA, Surette MG, Borenstein E, Vollmer W and Mougous JD (2017) A broadly distributed toxin family mediates contact-dependent antagonism between Gram-positive bacteria. eLife (Epub ahead of print).

Marmont LS, Rich JD, Whitney JC, Whitfield GB, Almblad H, Robinson H, Parsek MR, Harrison JJ and Howell PL (2017) Oligomeric lipoprotein PelC guides Pel polysaccharide export across the outer membrane of Pseudomonas aeruginosa. Proc Natl Acad Sci USA 114, 2892-2897.

2016

Eshraghi A, Kim J, Walls AC, Ledvina HE, Miller CN, Ramsey KM, Whitney JC, Radey MC, Peterson SB, Ruhland BR, Tran BQ, Goo YA, Goodlett DR, Dove SL, Celli J, Veesler D and Mougous JD (2016) Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth. Cell Host Microbe 5, 573-583.

Wexler AG, Bao Y, Whitney JC, Bobay LM, Schofield WB, Barry NA, Russell AB, Tran BQ, Goo YA, Goodlett DR, Ochman H, Mougous JD and Goodman AL (2016) Human symbionts continuously inject and neutralize antibacterial toxins to persist in the gut. Proc Natl Acad Sci USA 113, 3639-3644.

2015

Whitney JC, Quentin D, Sawai S, LeRoux M, Harding BN, Ledvina HE, Tran BQ, Robinson H, Goo YA, Goodlett DR, Raunser S, Mougous JD (2015) An interbacterial NAD(P)+ glycohydrolase toxin requires elongation factor Tu for delivery to target cells. Cell 163, 607-­619. (Preview written by Cabeen MT and Losick R. (2015) Bacterial Backstabbing: EF-­Tu, Brute? Cell 163, 537-­539.)

Whitney JC*, Whitfield GB*, Marmont LS, Yip P, Neculai AM, Lobsanov YD, Robinson H, Ohman DE, Howell PL (2015) Dimeric c-­di-­GMP is required for post-­translational regulation of alginate production in Pseudomonas aeruginosa. J Biol Chem 290, 12451-­ 12462. *Equal contribution

LeRoux M, Kirkpatrick RL, Montauti EI, Tran BQ, Peterson SB, Harding BN, Whitney JC, Russell AB, Traxler B, Goo YA, Goodlett DR, Wiggins PA, Mougous JD (2015) Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa. eLife doi: 10.7554/eLife.05701.

2014

Baker P, Ricer T, Moynihan PJ, Kitova EN, Walvoort MT, Little DJ, Whitney JC, Dawson K, Weadge JT, Robinson H, Ohman DE, Codée JD, Klassen JS, Clarke AJ, Howell PL (2014) Pseudomonas aeruginosa SGNH hydrolase-­like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylation. PLoS Pathog 10, e1004334.

Tan J, Rouse SL, Li D, Pye VE, Vogeley L, Brinth AR, El Arnaout T, Whitney JC, Howell PL, Sansom MS, Caffrey M (2014) A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa. Acta Crystallogr Sect D: Biol Crystallogr 70(Pt 8), 2054-­2068.

Russell AB, Wexler AG, Harding BN, Whitney JC, Bohn AJ, Goo YA, Tran BQ, Barry NA, Zheng H, Peterson SB, Chou S, Gonen T, Goodlett DR, Goodman AL, Mougous JD (2014) A type VI secretion-­related pathway in Bacteroidetes mediates interbacterial antagonism. Cell Host Microbe 16, 227-­236.

Whitney JC, Beck CM, Goo YA, Russell AB, Harding BN, De Leon JA, Cunningham DA, Tran BQ, Low DA, Goodlett DR, Hayes CS, Mougous JD (2014) Genetically distinct pathways guide effector export through the type VI secretion system. Mol Microbiol 92, 529-­542. (Highlighted as one of the 30 most influential papers published in Molecular Microbiology over the last 30 years)

2013

Whitney JC, Chou S, Russell AB, Biboy J, Gardiner TE, Ferrin MA, Brittnacher M, Vollmer W, Mougous JD (2013) Identification, structure and function of a novel type VI secretion peptidoglycan glycoside hydrolase effector–immunity pair. J Biol Chem 288, 26616-­26624.

Ali SS, Whitney JC, Stevenson J, Robinson H, Howell PL, Navarre WW (2013) Structural insights into the regulation of foreign genes in Salmonella by the Hha/H-­NS complex. J Biol Chem 288, 13356-­13369.

Colvin KM, Alnabelseya N, Baker P, Whitney JC, Howell PL, Parsek MR (2013) PelA deacetylase activity is required for Pel polysaccharide synthesis in Pseudomonas aeruginosa. J Bacteriol 195, 2329-­2339.

Whitney JC, Howell PL (2013) Synthase-­dependent exopolysaccharide secretion in Gram-­negative bacteria. Trends Microbiol 21, 63-­72. (Featured on cover of journal, recommended by Faculty of 1000)

2012

Guo S, Garnham CP, Whitney JC, Graham LA, Davies PL (2012) Re-­evaluation of a bacterial antifreeze protein as an adhesin with ice-­binding activity. PLoS One 7, e48805.

Little DJ, Poloczek J, Whitney JC, Robinson H, Yip P, Nitz M, Howell PL (2012) The structure and metal dependent activity of Escherichia coli PgaB provides insight into the partial de-­N-­acetylation of poly-­β-­1,6-­N-­acetyl-­D-­glucosamine. J Biol Chem 287, 31126-­31137.

Little DJ, Whitney JC, Robinson H, Yip P, Nitz M, Howell PL (2012) Crystallization and preliminary X-­ray analysis of Escherichia coli PgaB using in situ proteolysis and mass spectrometry. Acta Crystallogr Sect F: Struct Biol Cryst Commun 68(Pt 7), 842-­845.

Whitney JC, Colvin KM, Marmont LS, Robinson H, Parsek MR, Howell PL (2012) Structure of the cytoplasmic region of PelD, a degenerate diguanylate cyclase receptor that regulates PEL polysaccharide production in Pseudomonas aeruginosa. J Biol Chem 287, 23582-­23593.

Marmont LS, Whitney JC, Robinson H, Colvin KM, Parsek MR, Howell PL (2012) Expression, purification, crystallization and preliminary X-­ray analysis of Pseudomonas aeruginosa PelD. Acta Crystallogr Sect F: Struct Biol Cryst Commun 68(Pt 2), 181-­184.

Colvin KM, Irie Y, Tart CS, Urbano R, Whitney JC, Ryder C, Howell PL, Wozniak DJ, Parsek MR (2012) The PEL and PSL polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix. Environ Microbiol 14, 1913-­1928.

2008-2011

Whitney JC, Hay ID, Li C, Eckford PD, Robinson H, Amaya MF, Wood LF, Ohman DE, Bear CE, Rehm BH, Howell PL (2011) Structural basis for alginate secretion across the bacterial outer membrane. Proc Natl Acad Sci USA 108, 13083-­13088.

Keiski CL, Harwich M, Jain S, Neculai AM, Yip P, Robinson H, Whitney JC, Riley L, Burrows LL, Ohman DE, Howell PL (2010) AlgK is a TPR-­containing protein and the periplasmic component of a novel exopolysaccharide secretin. Structure 18, 265-­273.

Whitney JC, Neculai AM, Ohman DE, Howell PL (2009) Expression, refolding, crystallization and preliminary X-­ray analysis of Pseudomonas aeruginosa AlgE. Acta Crystallogr Sect F: Struct Biol Cryst Commun 65(Pt 5), 463-­466.

Le Marquand P, Tsui GC, Whitney JC, Tam W (2008) Iron-­catalyzed cross-­coupling reactions between a bicyclic alkenyl triflate and Grignard reagents. J Org Chem 73, 7829-­7832